WebJun 9, 2016 · Introduction. Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder that occurs in approximately 2% of the population, and is characterized by repetitive, persistent, intrusive thoughts and repetitive, compulsive behaviors [].Selective serotonin reuptake inhibitors (SSRIs) are the most common first-line treatment for … WebApr 30, 2010 · Overview of the i-GSEA algorithm. The i-GSEA4GWAS web server implements i-GSEA to help researchers explore GWAS data efficiently.i-GSEA is an application and extension of GSEA.For GSEA, it runs the following three key procedures. (i) The max statistics or −log(P-value) of closely spaced SNPs in a gene is used to …
Frontiers Shared genetic mechanism between type 2 diabetes …
http://gsea4gwas.psych.ac.cn/ WebMay 29, 2024 · Table 4 GSEA4GWAS analysis of the additive OS model. Gene Ontology Biological Process and Canonical Pathways terms with a BH-adjusted P-value < 0.25 are shown Full size table In this work we present evidence that suggest the existence of germline variation modulating CLL’s clinical aggressivity. tannoy reveal passive vs ns10
Genome-Wide Association Study-Driven Gene-Set Analyses ... - PubMed
WebDec 22, 2016 · This is the first Han Chinese GWAS analysing a total of 22,729 subjects from Singapore, Hong Kong, Malaysia, Korea, mainland China and Taiwan and observes strong associations reaching genome-wide significance at SNCA, LRRK2 and MCCC1, confirming their important roles in both European and Asian PD. Genome-wide association studies … WebGenome-wide association study (GWAS) is nowadays widely used to identify genes involved in human complex disease. The standard GWAS analysis examines SNPs/genes independently and identifies only a number of the most significant SNPs. It ignores the combined effect of weaker SNPs/genes, which leads to difficulties to explore biological … Webi-GSEA4GWAS 1.1:: DESCRIPTION. The i-GSEA4GWAS (improved GSEA for GWAS) web server is a web-based resource for analysis of GWAS data (typically each SNP’s -log(P-value)) to identify pathways/gene sets correlated to certain traits by implementing an improved Gene Set Enrichment Analysis (i-GSEA) approach. i-GSEA4GWAS aims to … tannoy revolution xt 8f sale