WebAug 22, 2024 · An efficient Chan–Lam-type methodology for the selective synthesis of S-arylbenzimidazoles and N,S-diarylbenzimidazoles was developed. The selectivity was controlled by varying the amount of the catalyst Cu(OAc)2·H2O, temperature, and solvent switching. These transformations feature a simple protocol, broad functional group … WebJul 23, 2015 · Chan-Lam cross coupling allowed efficient synthesis of N,N’-disubstituted ortho -phenylene diamines bearing strong electron donating or withdrawing groups, such …

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WebWe report a Chan–Lam coupling reaction of benzylic and allylic boronic esters with primary and secondary anilines to form valuable alkyl amine products. Both secondary and tertiary boronic esters can be used as coupling partners, with mono-alkylation of the aniline occurring selectively. WebApr 23, 2013 · For the first time, a general catalytic procedure for the cross-coupling of primary amides and alkylboronic acids is demonstrated. The key to the success of this reaction was the identification of a mild base (NaOSiMe3) and oxidant (di-tert-butyl peroxide) to promote the copper-catalyzed reaction in high yield. This transformation provides a … bouzou and co

Electrochemically Enabled Chan–Lam Couplings of Aryl Boronic …

WebChan-Lam coupling is one of the most popular and easy methods to perform arylation of amines (N-arylations). This cross-coupling is generally performed by reacting aryl boronate derivatives with a variety of substrates involving nitrogen containing functional groups such as amines, amides, ureas, hydrazine, carbamates. WebJul 15, 2016 · Chan–Lam coupling is a copper-catalysed N/O-arylation reaction using arylboronic acids. It has emerged as a powerful and useful synthetic methodology for medicinal, crop-protection and material chemists. The Chan–Lam coupling reaction is the only reaction that is capable of forming twelve C-element bonds (N, O, S, P, F, Cl, Br, I, … guisborough castle